Structure-activity dependency of new bacterial tryptophanyl tRNA synthetase inhibitors

DOI: 10.1016/0960-894X(96)00237-5

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1375 - 1380 (1996)

Update date:2022-08-04

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Authors:

Witty, David R.

Walker, Graham

Bateson, John H.

O'Hanlon, Peter J.

Cassels, Robert

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Article abstract of DOI:10.1016/0960-894X(96)00237-5

Analogues of the aminoacyl tRNA synthetase inhibitor, indolmycin, have been synthesised in which the side chain methyl group is replaced by a wide range of substituents. Their antibacterial and enzyme inhibitory potency is related to steric properties and

Full text of DOI:10.1016/0960-894X(96)00237-5

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