Non-peptidic, non-prenylic bisubstrate farnesyltransferase inhibitors. Effect of a carboxyl group at the central group on farnesyltransferase inhibitory activity

Article abstract of DOI:10.1211/146080800128735601

We recently described non-peptidic, non-prenylic bisubstrate analogues as novel farnesyltransferase inhibitors comprising three modules - a farnesyl-mimetic, a linker and an AAX-peptidomimetic substructure. In this study, we replaced the originally used β