Synthesis using ring closure metathesis and effect on nucleoside transport of a (N)-methanocarba S-(4-nitrobenzyl)thioinosine derivative

Article abstract of DOI:10.1021/ol006999c

(Matrix presented) A new synthetic route to ring-constrained (N)-methanocarba nucleosides and nucleotides is presented. Ring closure of a diene intermediate usina Grubbs catalyst provides a new avenue for the preparation of the cyclopentenone derivative 6