An efficient synthesis of 4-heterofunction-substituted 3-(1-hydroxy)ethylazetidin-2-ones from 3-(1-hydroxy)ethyl-4-phenylsulfinylazetidin-2-one by reaction with silylated heteronucleophiles

DOI: 10.1248/cpb.40.1733

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1733 - 1736 (1992)

Update date:2022-08-05

Topics: Solvent Deprotonation Temperature Workup Base Nucleophilic Attack

Authors:

Kita Kita

Shibata Shibata

Yoshida Yoshida

Tohjo Tohjo

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Article abstract of DOI:10.1248/cpb.40.1733

3-(1-tert-Butyldimethylsiloxy)ethyl-4-sulfinylazetidin-2-one was reacted with silylated N-, S-, O-, and P-nucleophiles in the presence of a catalytic amount of ZnI₂ to give the corresponding trans-4-heterofunction-substituted azetidin-2-ones in high yields.

Full text of DOI:10.1248/cpb.40.1733

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