An efficient synthesis of 4-heterofunction-substituted 3-(1-hydroxy)ethylazetidin-2-ones from 3-(1-hydroxy)ethyl-4-phenylsulfinylazetidin-2-one by reaction with silylated heteronucleophiles

DOI: 10.1248/cpb.40.1733

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1733 - 1736 (1992)

Update date:2022-08-05

Topics: Solvent Deprotonation Temperature Workup Base Nucleophilic Attack

Authors:

Kita Kita

Shibata Shibata

Yoshida Yoshida

Tohjo Tohjo

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.40.1733

3-(1-tert-Butyldimethylsiloxy)ethyl-4-sulfinylazetidin-2-one was reacted with silylated N-, S-, O-, and P-nucleophiles in the presence of a catalytic amount of ZnI₂ to give the corresponding trans-4-heterofunction-substituted azetidin-2-ones in high yields.

Full text of DOI:10.1248/cpb.40.1733

NII-Electronic Library Service

Products guided by the article

Product name:6-Methylthio-9-trimethylsilyl-9H-purine

Cas No:32865-87-5

R&D Labs maybe for 32865-87-5

Josun International Limited

website:http://www.josunpharma.com

Contact:+86-311-80715268 80766839

Address:No.39, Zhaiying Street, Shijaizhuang,Hebei,China
Tangshan Moneide Trading Co., Ltd.

Contact:+86-315-8309571

Address:2-7-420 Jidong Building Materials Commercial Center, Tangshan, Hebei, 064000 China
Ji'an Hairui Natural Plant Co. Ltd.

Contact:0796-8105528

Address:Meilin industry park, Qingyuan district Ji'an City, Jiangxi Province
Molobelamltrading

Contact:27-792-602929

Address:SIDNEY MUFAMADI STREET 009949 X44 0700 POLOKWANE,LIMPOPO
NINGBO YINLIANG FOREIGN TRADE CO., LTD.

Contact:+86-574-87834016 / 87898057

Address:23F NO.666JINYU ROAD,YINGZHOU DISTRICT,NINGBO.CHINA

Relevant to this article

Discovery and Pharmacophore Studies of Novel Pyrazole-Based Anti-Melanoma Agents

Doi:10.1002/cbdv.201400143
(2015)
2- and 3-substituted 1,4-naphthoquinone derivatives as subversive substrates of trypanothione reductase and lipoamide dehydrogenase from Trypanosoma cruzi: Synthesis and correlation between redox cycling activities and in vitro cytotoxicity

Doi:10.1021/jm001079l
(2001)
Lead(iv) complexes with phosphinoyldithioformates, R2P(O)CS2~ (R = Ph or PhCH₂). Syntheses and characterization. Crystal structures of PPhJ[S2CP(O)Ph2]-0.5H₂O, [PbPh2{S2CP(O)Ph2}2] and [PbPh2Cl{S2CP(O)Ph2}]

Doi:10.1039/b006672i
(2000)
Synthesis and antibacterial evaluation of tetrahydropyrimidine-5-carboxamide

Doi:10.14233/ajchem.2018.20850
(2018)
Preparation of novel 1,2,3-triazole furocoumarin derivatives via click chemistry and their anti-vitiligo activity

Doi:10.1039/C8RA09755K
(2019)
Bis-salicylaldiminato complexes of zinc. Examination of the catalyzed epoxide/co₂ copolymerization

Doi:10.1021/ic0006403
(2001)

Article Doi