Formation and reaction of N-acyl- and N-methanesulfonyl-1-(3,4-dimethoxy)benzyl-7-acetoxy-1,2,3,4,6,7-hexahydro- 7-methoxy-6-oxoisoquinolines (o-quinol acetates)

Article abstract of DOI:10.1016/S0040-4020(00)00934-0

Oxidation of N-acyl- and N-methanesulfonyl-1,2,3,4-tetrahydro-7-methoxyisoquinolin-6-ols (7) with lead tetraacetate in dichloromethane produced quantitatively title compounds (o-QAs) (8). Treatment of N-trifluoroacetyl and N-formyl o-QAs (8a,b) with aceti