STEREOSELECTIVE SYNTHESIS OF THE MIDDLE (C10-C17) AND RIGHT (C18-C30) SEGMENTS, AND THEIR COUPLING TO COMPLETE A FORMAL SYNTHESIS OF THE POLYETHER ANTIBIOTIC SALINOMYCIN

DOI: 10.1016/S0040-4039(00)95485-6

Source and publish data:

Tetrahedron Letters p. 3253 - 3256 (1987)

Update date:2022-08-05

Topics:

Authors:

Horita, Kiyoshi

Nagato, Satoshi

Oikawa, Yuji

Yonemitsu, Osamu

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Article abstract of DOI:10.1016/S0040-4039(00)95485-6

The middle (C10-C17) and right (C18-C30) segments of the polyether antibiotic salinomycin were stereoselectively synthesized from D-glucose, D-mannitol, and ethyl L-lactate.Coupling of the two segments followed by construction of the bisketal ring system gave the C10-C30 segment, which was already converted to salinomycin by Kishy.

Full text of DOI:10.1016/S0040-4039(00)95485-6

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