
Tetrahedron Letters p. 3253 - 3256 (1987)
Update date:2022-08-05
Topics:
Horita, Kiyoshi
Nagato, Satoshi
Oikawa, Yuji
Yonemitsu, Osamu
The middle (C10-C17) and right (C18-C30) segments of the polyether antibiotic salinomycin were stereoselectively synthesized from D-glucose, D-mannitol, and ethyl L-lactate.Coupling of the two segments followed by construction of the bisketal ring system gave the C10-C30 segment, which was already converted to salinomycin by Kishy.
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