Tetrahedron Letters p. 3297 - 3300 (1992)
Update date:2022-09-26
Topics:
Maliakel, Balu P.
Schmid, Walther
A novel synthesis for sphydrofuran 1 has been developed.Starting with achiral materials the chiral centers of the target molecule were introduced via enzymatic methods as well as via a diastereoselective Grignard reaction.Rabbit muscle aldolase (RAMA)-catalyzed aldol condensation of chloroacetaldehyde 3 with dihydroxyacetone phosphate (DHAP) 4 affords the C-5 skeleton of 5 which was transformed to sphydrofuran 1 and its analogue 10 via a Grignard addition of allylmagnesium bromide followed by a Wacker reaction.
View MoreContact:+1 (647) 918 5848
Address:2343 BRIMLEY RD., Suite 250
Daicel Chiral Technologies (China)CO.,LTD
Contact:021-5046-0086*8
Address:Part C, FL 5, the 16th Building, No. 69, XiYa Road, WaiGaoQiao Free Trade Zone, Shanghai, 200131, P.R.China
Contact:+1-973-357-0577
Address:10 Taft Rd.
RongCheng Tianyu Technology Co.,Ltd.
Contact:86-631-7519595
Address:220Ping Donghai Road RongChengCity,ShangDong Province China
Improve Medical Technology(Nanxiong) Co., Ltd
Contact:86-751-3836997
Address:No.33, Pingan First Road, Fine Chemical Industry Base, Nanxiong City, Shaoguan, Guangdong, China
Doi:10.1002/cjoc.201090225
(2010)Doi:10.1246/cl.2001.248
(2001)Doi:10.1248/cpb.54.58
(2006)Doi:10.1021/ma60022a001
(1971)Doi:10.1021/jp9809336
(1998)Doi:10.1021/ol015712o
(2001)
