Bioorganic and Medicinal Chemistry Letters p. 533 - 536 (2001)
Update date:2022-08-03
Topics:
Dini
Drochon
Guillot
Mauvais
Walter
Aszodi
O-β-D-Ribofuranosyl nucleoside I is the minimal structural entity of liposidomycins that maintains enzyme inhibitory activity on MraY. A set of compounds with hydroxyl patterns different from I has been synthesized. The presence of a hydroxyl group in the 3″ position is essential for the activity. The 3′-deoxy derivative (IV), however, shows a 5-fold improved potency.
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(2002)