Organic Letters
Letter
species D, of which further reductive elimination delivered Pd0
species, and the final benzamide product 3 was obtained via
tautomerization. On the other hand, in the presence of an
excess amount of 1, a second transmetalation between C and 1
gave intermediate F, which further conducts reductive
elimination to afford Pd0 species, and the final benzophenone
product 4 was obtained via hydrolysis. At last, Pd0 could be co-
oxidized by CuII and air to finish the catalytic cycle.9
In summary, we have successfully developed a palladium-/
copper-catalyzed oxidative cross-coupling of arylboronic acids
with isocyanides for the selective synthesis of amides and diaryl
ketones. Different substituted benzamides and benzophenones
could be obtained in good yields. Initial mechanistic studies
revealed that the product carbonyl oxygen originated from
water. This reaction represents an efficient and alternative
strategy for the synthesis of carbonyl compounds. Further
studies on reaction mechanism are currently underway.
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ASSOCIATED CONTENT
* Supporting Information
■
S
The Supporting Information is available free of charge on the
1
Experimental procedure, characterization data, and H,
AUTHOR INFORMATION
Corresponding Authors
■
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ORCID
Notes
The authors declare no competing financial interest.
ACKNOWLEDGMENTS
This work was supported by Jiangxi Provincial Education
Department Foundation (GJJ160325).
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