Studies of benzoxazines 16*. synthesis and reactivity of 2,4-substituted 4H-3,1-benzoxazines

Article abstract of DOI:10.1007/s10593-012-0928-z

A novel method has been developed for preparation of substituted 4H-3,1-benzoxazines via formation of tetrafluoroborates. The substitution of halogen in 2-(α-haloalkyl)-4,4-diphenyl-4H-3,1-benzoxazines by NH and SH nucleophiles was performed. The effect of electrophilic substitution in the annelated aromatic ring in a series of 2,4-substituted 4H-3,1-benzoxazines has been studied.