Chemoenzymatic synthesis of functionalized cyclohexylglycines and α-methylcyclohexylglycines via Kazmaier-Claisen rearrangement

DOI: 10.1016/S0960-894X(01)00013-0

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 627 - 629 (2001)

Update date:2022-09-26

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Authors:

Hudlicky, Tomas

Oppong, Kofi

Duan, Caiming

Stanton, Charles

Laufersweiler, Matthew J.

Natchus, Michael G.

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Article abstract of DOI:10.1016/S0960-894X(01)00013-0

The synthesis of homochiral functionalized cyclohexylglycines and α-methylcyclohexylglycines via chelated Kazmaier-Claisen rearrangement is described. These were shown to be potent scaffolds for the development of MMP inhibitors.

Full text of DOI:10.1016/S0960-894X(01)00013-0

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