A "green" synthesis of N-(quinoline-3-ylmethylene)benzohydrazide derivatives and their cytotoxicity activities

Article abstract of DOI:10.1590/S0103-50532011000900017

We report some hybrid molecules based on N-(quinoline-3-ylmethylene) benzohydrazide template the synthesis of which was carried out using 2-chloroquinoline-3-carbaldehyde and a variety of substituted hydrazides in PEG 400. The "green" solvent PEG 400 was recovered and reused for several times in the present reaction and was found to be effective in terms of product yield. Some of the compounds synthesized showed significant cytotoxic activity when tested in vitro. ?2011 Sociedade Brasileira de Qui?mica.