Carboxylic acid bioisosteres of γ-linked dipeptide analogues of the folate-based thymidylate synthase (TS) inhibitor, 2-desamino-2-methyl-N10-propargyl-5,8-dideazafolic acid (ICI 198583)

DOI: 10.1016/0960-894X(96)00078-9

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 631 - 636 (1996)

Update date:2022-08-03

Topics:

Authors:

Bavetsias

Jackman Jackman

Kimbell Kimbell

Boyle Boyle

Bisset Bisset

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Article abstract of DOI:10.1016/0960-894X(96)00078-9

Tetrazole carboxylic acid bioisosteres of γ-linked dipeptide derivatives of 2-desamino-2-methyl-N¹⁰-propargyl-5,8-dideazafolic acid (ICI 198583), a folate-based inhibitor of thymidylate synthase (TS), were synthesised by multistep routes starti

Full text of DOI:10.1016/0960-894X(96)00078-9

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