2,5-diarylisothiazolone: Novel inhibitors of cytokine-induced cartilage destruction

DOI: 10.1016/0968-0896(96)00053-3

Source and publish data:

Bioorganic and Medicinal Chemistry p. 851 - 858 (1996)

Update date:2022-08-04

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Authors:

Wright, Stephen W.

Petraitis, Joseph J.

Freimark, Bruce

Giannaras, John V.

Pratta, Michael A.

Sherk, Susan R.

Williams, Jean M.

Magolda, Ronald L.

Arner, Elizabeth C.

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Article abstract of DOI:10.1016/0968-0896(96)00053-3

A series of 2,5-diarylisothiazolones is reported that inhibit the IL-1β- induced breakdown of bovine nasal septum cartilage in an organ culture assay. The synthesis and preliminary SAR of these compounds are described. These compounds represent a novel, n

Full text of DOI:10.1016/0968-0896(96)00053-3

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