Bioorganic and Medicinal Chemistry p. 851 - 858 (1996)
Update date:2022-08-04
Topics:
Wright, Stephen W.
Petraitis, Joseph J.
Freimark, Bruce
Giannaras, John V.
Pratta, Michael A.
Sherk, Susan R.
Williams, Jean M.
Magolda, Ronald L.
Arner, Elizabeth C.
A series of 2,5-diarylisothiazolones is reported that inhibit the IL-1β- induced breakdown of bovine nasal septum cartilage in an organ culture assay. The synthesis and preliminary SAR of these compounds are described. These compounds represent a novel, n
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