C-2 SIDE CHAIN ALKYLATION OF 2-METHYL-3-ALKYLINDOLES VIA 3-METHOXYINDOLENINES

DOI: 10.1016/S0040-4039(00)86960-9

Source and publish data:

Tetrahedron Letters p. 829 - 832 (1982)

Update date:2022-08-04

Topics:

Authors:

Vice, Susan F.

Gross, Edward A.

Friesen, Richard W.

Dmitrienko, Gary I.

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Article abstract of DOI:10.1016/S0040-4039(00)86960-9

3-Methoxyindolenines derived from 2-methyl-3-alkylindoles by bromination-methanolysis undergo base induced alkylation and aldol condensations at the C-2 methyl group.The modified indolenines can be efficiently converted to C-2-side chain alkylated indoles

Full text of DOI:10.1016/S0040-4039(00)86960-9

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