WITTIG-HORNER REACTION OF A PHOSPHONATE OF REISSERT ANALOGUE A NEW METHOD FOR INTRODUCTION OF ALKYL GROUPS INTO ISOQUINOLINE

DOI: 10.1016/S0040-4039(01)92396-2

Source and publish data:

Tetrahedron Letters p. 4977 - 4980 (1981)

Update date:2022-07-30

Topics:

Authors:

Akiba, Kin-ya

Negishi, Yoshio

Kurumaya, Katsuyuki

Ueyama, Noboru

Inamoto, Naoki

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Article abstract of DOI:10.1016/S0040-4039(01)92396-2

Dimethyl 2-isopropoxycarbonyl-1,2-dihydroisoquinoline-1-phosphonate (1) was prepared from isoquinoline, isopropyl chloroformate, and trimethyl phosphite.Wittig-Horner reaction of 1 with various aldehydes afforded the corresponding exo-methylene compounds,

Full text of DOI:10.1016/S0040-4039(01)92396-2

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