Synthesis of N-protected 14C-labelled (2E)-5-amino-5-methylhex-2-enoic acid analogues

Article abstract of DOI:10.1002/jlcr.456

A novel method of preparing N-protected (2E)-5-amino-5-methylhex-2-enoic acids has been developed based on the synthesis of 3-methyl-3-amino-butanol. The method was used to synthesise ¹⁴C-labelled compounds of (1) via synthesis of triethylphosphono[1-¹⁴C]acetate.