Organic letters p. 1893 - 1896 (2001)
Update date:2022-08-05
Topics:
Herscovici
Egron
Quenot
Leclercq
Leforestier
Mignet
Wetzer
Scherman
[see structure]. We report the synthesis of new cationic lipids. These amphiphiles present a hydrophobic domain connected to a guanidinium entity by an unsaturated glycoside scaffold. The synthetic strategy using amide or acetal linkage led to various mono- and bicatenar derivatives. Investigation of their physicochemical properties indicated that these new compounds compact DNA.
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