Tetrahedron (2021)
Update date:2022-09-26
Topics:
An, Yu
Xu, Gang
Cai, Menglu
Wang, Shihui
Wang, Xiao zhong
Chen, Yingqi
Dai, Liyan
Phenylthio heterocyclic compounds are widely used because of their diverse biological activities and medicinal prospects. Here, a facile method was reported. An arylation of 1,3,4-oxa(thia)diazol-2-thiones reacting with arynes to build C(aryl)-S bonds in the presence of CsF had good yields and excellent selectivity. The reaction was completed in short time without using expensive reagents and catalysts. Present reaction system is an efficient procedure to process phenylthio heterocyclic compounds and reveals a sustainable method and better application prospects in future organic synthesis.
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Hebei Lead Bio-Chemicals Co., Ltd.
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Synochem Ingredients Corp., Ltd.
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