Tetrahedron Letters p. 6446 - 6449 (2011)
Update date:2022-08-05
Topics: Regioselectivity Green chemistry Purification Lead Optimization Chemoselectivity Reaction Kinetics Catalysis Structure-Activity Relationship (SAR) Reaction Monitoring High-Throughput Screening (HTS) Heterocyclic Chemistry Spectroscopic Characterization Scaffold Hopping Parallel Synthesis Bioisosteres Reaction yield Solvent Optimization Synthetic efficiency
Cagide, Fernando
Reis, Joana
Gaspar, Alexandra
Borges, Fernanda
Microwave irradiation offers a considerable advantage over conventional synthesis with rate enhancements and cleaner reactions. Accordingly, a new microwave-assisted method for the synthesis of func-tionalized chromones was developed allowing the obtention of a library of chromone carboxamides. The method has been shown to present several advantages including operational simplicity, good performance, significant reduction in reaction time, less formation of by-products, and easier work-up.
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