Tetrahedron Letters p. 5253 - 5256 (2001)
Update date:2022-08-05
Topics:
Noguchi, Yasuo
Uchiro, Hiromi
Yamada, Tatsuhiro
Kobayashi, Susumu
The first synthesis of (2S,3R)-3-hydroxy-3-methylproline, which is a novel amino acid of polyoxypeptin, a potent inducer of apoptosis in human pancreatic carcinoma AsPC-1, was accomplished. The key feature of the synthesis is the palladium-catalyzed intra
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