Journal of Organic Chemistry p. 4236 - 4245 (2019)
Update date:2022-08-04
Topics:
Fan, Zhenwei
Pan, Zhangjin
Huang, Liangsen
Cheng, Jiajia
A divergent synthetic strategy to 1,6-dihydropyridazines and pyridazines through Cu(II)-catalyzed controllable aerobic 6-endo-trig cyclization was developed. The selectivity can be rationally tuned via the judicious choice of reaction solvent. It was found that the 1,6-dihydropyridazines were obtained in moderate to high yields with CH3CN as the reaction solvent, whereas employment of AcOH directly afforded pyridazines in up to 92% yields, probably arising from the oxidation of the in situ generated 1,6-dihydropyridazines.
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