2-Ethyl and 2-ethylidene analogues of 1α,25-dihydroxy-19-norvitamin D3: Synthesis, conformational analysis, biological activities, and docking to the modeled rVDR ligand binding domain

Article abstract of DOI:10.1021/jm020007m

Novel 19-nor analogues of 1α,25-dihydroxyvitamin D₃ were prepared and substituted at C-2 with an ethylidene group. The synthetic pathway was via Wittig - Horner coupling of the corresponding A-ring phosphine oxides with the protected 25-hydroxy