
Nucleosides and Nucleotides p. 1543 - 1548 (1999)
Update date:2022-07-29
Topics:
Seela, Frank
Wei, Changfu
Melenewski, Alexander
He, Yang
Kroeschel, Rita
Feiling, Elisabeth
Parallel-stranded (ps) oligonucleotide duplexes containing several new base pairs formed between 7-deazaisoguanine and cytosine, 8-aza-7-deaza- isoguanine and cytosine, and 5-aza-7-deaza guanine and guanine are described. The stability of the ps-hybrids increased if the duplex contains 8-aza-7- deazaisoguanine instead of isoguanine and is decreased by 7-deazaisoguanine incorporation. The purine-purine base pair between 5-aza-7-deazaguanine and guanine was found to be more stable than that of 5-methylisocytosine with guanine.
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