Synthesis and conformational properties of N-monoalkyl 1,5-diaza-cis-decalins

Article abstract of DOI:10.1016/S0040-4039(01)01344-2

N-Monoalkyl 1,5-diaza-cis-decalins were synthesized in high yield and purity by derivatization of tetrahydronaphthyridine followed by reduction to the saturated system. The position of the conformational equilibrium between the chair-chair inversion forms of a series of four N-monoalkyl of 1,5-diaza-cis-decalins was measured and was directly related to the size of the N-alkyl group.