Bioorganic and Medicinal Chemistry Letters p. 2469 - 2473 (2001)
Update date:2022-08-03
Topics:
Finke, Paul E.
Meurer, Laura C.
Oates, Bryan
Shah, Shrenik K.
Loebach, Jennifer L.
Mills, Sander G.
MacCoss, Malcolm
Castonguay, Laurie
Malkowitz, Lorraine
Springer, Martin S.
Gould, Sandra L.
DeMartino, Julie A.
Structure-activity relationship studies directed toward the optimization of (2S)-2-(3-chlorophenyl)-1-[N-(methyl)-N-(phenylsulfonyl)amino]-4-[4- (substituted)piperidin-1-yl]butanes as CCR5 antagonists resulted in the synthesis of the spiro-indanone derivative 8c (IC50 = 5 nM). These and previous results are summarized in a proposed pharmacophore model for this class of CCR5 antagonist.
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Doi:10.1021/ja00899a049
(1963)Doi:10.1016/S0008-6215(00)85364-1
(1980)Doi:10.1021/jo00984a034
(1972)Doi:10.1021/ja047004e
(2004)Doi:10.1016/0021-9797(71)90140-8
(1971)Doi:10.1021/jo01278a056
(1967)
