Conformationally constrained serotonin analogues: Stereoselective synthesis of trans-3-(2-aminocycloalkyl)indoles by aziridine ring opening

DOI: 10.1016/0040-4039(95)02242-2

Source and publish data:

Tetrahedron Letters p. 683 - 686 (1996)

Update date:2022-08-04

Topics:

Authors:

Ezquerra

Pedregal

Lamas Lamas

Pastor Pastor

Alvarez Alvarez

Vaquero Vaquero

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Article abstract of DOI:10.1016/0040-4039(95)02242-2

Trans-3-(2-aminocyclopentyl)indoles 9a,c and trans-3-(2-aminocyclohexyl)indoles 9b,d have been stereoselectively prepared by nucleophilic ring opening reaction of N-Boc cycloalkylaziridines 6a,b and the 'lower order' magnesium cuprate II, generated from the corresponding indolilmagensium bromides derived from 7a,b.

Full text of DOI:10.1016/0040-4039(95)02242-2

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