Isosteric Compounds according to the Hydride Principle of Grimm in the Range of Linalool Scents

Article abstract of DOI:10.1007/BF00813801

Substitution of the (CH3)2CH=CH group by (CH3)2C=N in linalool as well as by the (CH3)2CH-CH2 group in linalool and in sila-linalool does not lead to noticeable changes of their scent qualities.On the contrary, substitution of the OH group at the tertiary C atom by NH2 or CH3 - hydride isosteric to OH according to Grimm - affords fishy or etheric instead of the original flowery smells thus indicating a transition to different basic classes of odor.Similar results were obtained with the linalool-like scents of benzyldimethylcarbinol and phenylethyldimethylcarbinol.Therefor the theory of Amoore, after which only shape and size of molecules are ruling their odor qualities, must be called in question. - Keywords: Perfumes; Sila Perfumes; Isosteric Compounds; Silazanes; Olfactoric Theories.