Welcome to LookChem.com Sign In|Join Free

Article Doi

Cyclization of the acyl glucuronide metabolite of a neutral endopeptidase inhibitor to an electrophilic glutarimide: Synthesis, reactivity, and mechanistic analysis

DOI: 10.1021/jm0706766

Source and publish data:

Journal of Medicinal Chemistry p. 6165 - 6176 (2007)

Update date:2022-08-05

Topics:

Authors:

Meng, XiaoliMeng, Xiaoli

Maggs, James L.Maggs, James L.

Pryde, David C.Pryde, David C.

Planken, SimonPlanken, Simon

Jenkins, Rosalind E.Jenkins, Rosalind E.

Peakman, Torren M.Peakman, Torren M.

Beaumont, KevinBeaumont, Kevin

Kohl, ChristopherKohl, Christopher

Park, B. KevinPark, B. Kevin

Stachulski, Andrew V.Stachulski, Andrew V.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm0706766

The neutral endopeptidase inhibitor (2R)-2-[(1-{[(5-ethyl-1,3,4-thiadiazol- 2-yl)amino]carbonyl}cyclopentyl)-methyl]pentanoic acid 2 is metabolized to acyl glucuronide 3. Unprecedentedly, at pH 7.4, 3 does not undergo the O-acyl migration characteristic o

View More

Full text of DOI:10.1021/jm0706766

Products guided by the article

Product name:Cyclopentanecarboxylic acid, 1-[(2R)-2-[[(5-ethyl-1,3,4-thiadiazol-2-yl)amino]carbonyl]pentyl]-, phenylmethyl ester

Cas No:388631-32-1

388631-32-1

R&D Labs maybe for 388631-32-1

Relevant to this article

Hot Product