Journal of the American Chemical Society p. 8330 - 8339 (2018)
Update date:2022-09-26
Topics:
Ahmed, Jasimuddin
Chakraborty, Soumi
Jose, Anex
Sreejyothi
Mandal, Swadhin K.
In recent years, merging different types of catalysis in a single pot has drawn considerable attention and these catalytic processes have mainly relied upon metals. However, development of a completely metal free approach integrating organic redox and organic Lewis acidic property into a single system has been missing in the current literature. This study establishes that a redox active phenalenyl cation can activate one of the substrates by single electron transfer process while the same can activate the other substrate by a donor-acceptor type interaction using its Lewis acidity. This approach has successfully achieved light and metal-free catalytic C-H functionalization of unactivated arenes at ambient temperature (39 entries, including core moiety of a top-selling molecule boscalid), an economically attractive alternative to the rare metal-based multicatalysts process. A tandem approach involving trapping of reaction intermediates, spectroscopy along with density functional theory calculations unravels the dual role of phenalenyl cation.
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Doi:10.1134/S1070363206020241
(2006)Doi:10.1021/ja01548a030
()Doi:10.1002/asia.201800103
(2018)Doi:10.1016/S0040-4020(01)93853-0
(1972)Doi:10.1039/P19720003015
(1972)Doi:10.1021/om000939t
(2002)