The preparation of α-substituted, β-hydroxy piperidines and pyrrolidines: The total synthesis of febrifugine

Article abstract of DOI:10.1016/0040-4039(96)00527-8

Epoxides generated from cyclic ene carbamates are effective N-acyl iminium ion precursors and allow for the preparation of β-hydroxy, α-substituted piperidines and pyrrolidines. The total synthesis of racemic Febrifugine is also described.