Bioorganic and Medicinal Chemistry Letters p. 735 - 738 (1998)
Update date:2022-08-03
Topics:
Kim, Sang Woong
Hong, Chang Yong
Lee, Koo
Lee, Eun Ju
Koh, Jong Sung
Using solid phase synthesis, a library has been constructed of benzylamine-derived sulfonamides which have strong inhibitory activity against the blood coagulant thrombin. The library compounds were obtained in good yield and high purity; four of these thrombin inhibitors showed nanomolar potency (Ki 600-10 nM).
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