Solid phase synthesis of benzylamine-derived sulfonamide library

DOI: 10.1016/S0960-894X(98)00114-0

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 735 - 738 (1998)

Update date:2022-08-03

Topics:

Authors:

Kim, Sang Woong

Hong, Chang Yong

Lee, Koo

Lee, Eun Ju

Koh, Jong Sung

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Article abstract of DOI:10.1016/S0960-894X(98)00114-0

Using solid phase synthesis, a library has been constructed of benzylamine-derived sulfonamides which have strong inhibitory activity against the blood coagulant thrombin. The library compounds were obtained in good yield and high purity; four of these thrombin inhibitors showed nanomolar potency (Ki 600-10 nM).

Full text of DOI:10.1016/S0960-894X(98)00114-0

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