Journal of Asian Natural Products Research p. 956 - 965 (2020)
Update date:2022-08-05
Topics:
Song, Shu-Lian
Lian, Cheng-Xi
Chen, Li-Ping
Huang, Long-Liang
First synthesis of the diastereomeric mixture of salbutamol impurity F is described in seven steps by using 4-hydroxyacetophenone as starting material, with 15.2percent total yield. The synthesis provides access to multi-gram quantities of impurity F with good purity for reference supplies and further analytical and toxicology investigations. (Figure presented.).
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