Efficient Enantiospecific Synthesis of Key A-Ring Synthons for the Preparation of 1α,25-Dihydroxyvitamin D3 Using a Chromium((II)-Mediated Reaction

Article abstract of DOI:10.1021/jo00276a003

Key A-ring synthons for the synthesis of 1α,25-dihydroxyvitamin D₃ have been prepared efficiently from (R)-(-)-carvone by use of diastereoselective chromium(II)-mediated addition of an allylic halide to an aldehyde as a key step.