Bioorganic and Medicinal Chemistry Letters p. 2981 - 2983 (2002)
Update date:2022-08-04
Topics:
Hamilton, Harriet W.
Nishiguchi, Gisele
Hagen, Susan E.
Domagala, John D.
Weber, Peter C.
Gracheck, Stephen
Boulware, Stefanie L.
Nordby, Eric C.
Cho, Hidetsura
Nakamura, Takeshi
Ikeda, Satoru
Watanabe, Wataru
A series of novel benzthiodiazepinones was studied as antiherpetic agents. Significant improvements in potency and therapeutic index in a viral replication assay were realized over the starting molecule. The role of stereospecific substitution on the diazepine ring and optimal nitrogen substitution were investigated.
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Doi:10.1002/jhet.5570400403
(2003)Doi:10.1016/0031-9422(83)80050-8
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(2016)
