The Remarkably High Reactivity of α-Cyano-α-fluorophenylacetyl Chloride (CFPA-Cl) towards Hindered Nucleophiles in Enantiomeric Excess Determination

DOI: 10.1039/c39920001514

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 1514 - 1515 (1992)

Update date:2022-07-29

Topics: Reactivity Enantiomeric excess Chemical Reaction

Authors:

Takeuchi, Yoshio

Itoh, Noriaki

Koizumi, Toru

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Article abstract of DOI:10.1039/c39920001514

The reaction of PhCF(CN)COCl 2b with 3,3-dimethylbutal-2-ol 5 was found to proceed more than 500 times faster than that of PhCCF3(OMe)COCl (MTPA-Cl) 1b, suggesting that the CFPA method should potentially lead to much less kinetic resolution than the curre

Full text of DOI:10.1039/c39920001514

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