Bioorganic and Medicinal Chemistry Letters p. 1028 - 1031 (2006)
Update date:2022-08-04
Topics:
Cherney, Robert J.
King, Bryan W.
Gilmore, John L.
Liu, Rui-Qin
Covington, Maryanne B.
Duan, James J.-W.
Decicco, Carl P.
Novel sultam hydroxamates with potent MMP activity were transformed into potent TACE inhibitors, lacking MMP activity. To accomplish this we relied on structural differences between the MMP and TACE S1′ pockets and the known advantageous fit of a 2-methyl
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