Stereoselective 7α-hydroxylation of 3β-acetoxy-Δ5-steroids by Fe(PA)3/H2O2/MeCN

DOI: 10.1248/cpb.45.750

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 750 - 752 (1997)

Update date:2022-07-30

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Authors:

Kotani, Eiichi

Takeya, Tetsuya

Egawa, Hirotaka

Tobinaga, Seisho

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Article abstract of DOI:10.1248/cpb.45.750

Stereoselective 7α-hydroxylation reaction of Δ⁵-steroids by a Fe(PA; picolinate)₃/H₂O₂/MeCN system is presented. The 7α-hydroxylation reactions were achieved in 33-40% yields by addition of 30%-H₂O₂ to a solution of 3β-acetoxy-Δ₅-steroids 1a-1d and a crystalline of Fe(PA)₃ in MeCN.

Full text of DOI:10.1248/cpb.45.750

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