Welcome to LookChem.com Sign In|Join Free

Article Doi

Synthesis of 5-aryl-1,3,4-oxadiazolyl-2-acetic acids

DOI: 10.1515/HC.2001.7.5.411

Source and publish data:

Heterocyclic Communications p. 411 - 416 (2001)

Update date:2022-09-26

Topics:

Authors:

Janda, LubomirJanda, Lubomir

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1515/HC.2001.7.5.411

Ethyl (1H-tetrazol-5-yl)acetate is acylated with aroyl chlorides and heteroaroyl chlorides in pyridine. The intermediate acyltetrazoles undergo thermal degradation to ethyl (5-aryl-1,3,4-oxadiazol-2-yl)acetates and (5-heteroaryl-1,3,4-oxadiazol-2-yl)acetates, respectively, in good yields. The corresponding acetic acids are obtained by potassium hydroxide mediated hydrolysis of the esters in anhydrous ethanol.

View More

Full text of DOI:10.1515/HC.2001.7.5.411

Brought to you by | Purdue University Libraries  
Authenticated  
Download Date | 5/30/15 11:18 PM  
Brought to you by | Purdue University Libraries  
Authenticated  
Download Date | 5/30/15 11:18 PM  
Brought to you by | Purdue University Libraries  
Authenticated  
Download Date | 5/30/15 11:18 PM  
Brought to you by | Purdue University Libraries  
Authenticated  
Download Date | 5/30/15 11:18 PM  
Brought to you by | Purdue University Libraries  
Authenticated  
Download Date | 5/30/15 11:18 PM  
Brought to you by | Purdue University Libraries  
Authenticated  
Download Date | 5/30/15 11:18 PM  

Products guided by the article

Product name:[5-(2-METHOXY-PHENYL)-[1,3,4]OXADIAZOL-2-YL]-ACETIC ACID

Cas No:415679-26-4

415679-26-4

R&D Labs maybe for 415679-26-4

Relevant to this article

Hot Product