
Heterocyclic Communications p. 411 - 416 (2001)
Update date:2022-09-26
Topics:
Janda, Lubomir
Ethyl (1H-tetrazol-5-yl)acetate is acylated with aroyl chlorides and heteroaroyl chlorides in pyridine. The intermediate acyltetrazoles undergo thermal degradation to ethyl (5-aryl-1,3,4-oxadiazol-2-yl)acetates and (5-heteroaryl-1,3,4-oxadiazol-2-yl)acetates, respectively, in good yields. The corresponding acetic acids are obtained by potassium hydroxide mediated hydrolysis of the esters in anhydrous ethanol.
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