4-Heterocyclyl tetrahydropyridines as selective ligands for the human dopamine D4 receptor.

Article abstract of DOI:10.1016/S0960-894X(97)00402-2

A series of 1,2,3,6-tetrahydropyridines 3 were synthesised, which resulted in selective high affinity dopamine D₄ ligands. The SAR of heterocyclic replacements and aromatic substitution was investigated, leading to compounds of nanomolar bindin