Bioorganic and Medicinal Chemistry Letters p. 2211 - 2216 (1997)
Update date:2022-08-03
Topics:
Haworth
Harrison
Kulagowski
Leeson
Owens
Ridgill
Teall
Fielding
Chapman
Emms
Marwood
Patel
Moss
A series of 1,2,3,6-tetrahydropyridines 3 were synthesised, which resulted in selective high affinity dopamine D4 ligands. The SAR of heterocyclic replacements and aromatic substitution was investigated, leading to compounds of nanomolar bindin
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