Tetrahedron p. 2137 - 2142 (1981)
Update date:2022-07-31
Topics:
Angiolini, L.
Bizzarri, P. Costa
Scapini, G.
Tramontini, M.
The stereoselectivity of the title reactions due to a hindering amino group in α-asymmetric aminoketones (1 and 2) and to an asymmetric center far away from the reaction center in β-(methylpiperidino)-ketones (11-14) has been studied.The aminoalcohols obtained (3-8 and 15-22) have been separated in most cases and the relative configurations attributed by NMR.Based on diastereomeric ratios, a N-coordinated cyclic transition state has been proposed and is, effective for the Grignard reactions on the β-aminoketone system.
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