Desymmetrization of Phosphinic Acids via Pd-Catalyzed Asymmetric Allylic Alkylation: Rapid Access to P-Chiral Phosphinates

Article abstract of DOI:10.1021/jacs.9b07340

The synthesis of P-chiral compounds is challenging, especially since useful catalytic methods for preparing such molecules are scarce. Herein we disclose a desymmetrization that employs phosphinic acids as prochiral nucleophiles in a Pd-catalyzed asymmetr

Full text of DOI:10.1021/jacs.9b07340

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Communication
Desymmetrization of Phosphinic Acids via Pd-Catalyzed Asymmetric
Allylic Alkylation – Rapid Access to P-Chiral Phosphinates
Barry M. Trost, Simon Marcel Spohr, Alessa Rolka, and Christopher A. Kalnmals
J. Am. Chem. Soc., Just Accepted Manuscript • DOI: 10.1021/jacs.9b07340 • Publication Date (Web): 23 Aug 2019
Downloaded from pubs.acs.org on August 23, 2019
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O
O
O
O
NH HN
PPh2 Ph2P
(S,S)-L1
NH HN
PPh2 Ph2P
(S,S)-L2
Ph
Ph
O
O
O
O
NH HN
NH HN
PPh2 Ph2P
PPh2 Ph2P
(S,S)-L3
(S,S)-L4
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[ ]24
훼
퐷
[ ]20
훼
퐷
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