In silico identification of poly(ADP-ribose)polymerase-1 inhibitors and their chemosensitizing effects against cisplatin-resistant human gastric cancer cells

DOI: 10.1016/j.bmcl.2013.02.094

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2642 - 2646 (2013)

Update date:2022-08-03

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Authors:

Le, Tuong Vy Thi

Suh, Jee Hee

Kim, Nakjeong

Park, Hyun-Ju

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Article abstract of DOI:10.1016/j.bmcl.2013.02.094

Poly(ADP-ribose)polymerase-1 (PARP-1) enzyme is involved in the repair of DNA damages made by certain anticancer agents. It is suggested that PARP-1 inhibitors potentiate the cytotoxic effects and circumvent the resistance of DNA-modifying anticancer agen

Full text of DOI:10.1016/j.bmcl.2013.02.094

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