Preparation of a useful synthetic precursor, 2-substituted 4(3h)-quinazolinone: Directed lithiation and N3-deprotection of 3-t-butoxycarbonyl-4(3h)-quinazolinone

Article abstract of DOI:10.3987/COM-01-9386

Directed lithiation of 3-t-butoxycarbonyl-4(3H)-quinazolinone using LDA was accomplished to afford 2-substituted 3-t-butoxycarbonyl-4(3H)-quinazolinones. The t-butoxycarbonyl group of these products was easily deprotected to give key intermediates for the