Bioorganic and Medicinal Chemistry Letters p. 1259 - 1262 (2002)
Update date:2022-09-26
Topics:
Charles
Xue, Liang
Arya, Dev P.
Development of aminoglycoside-nucleic acid conjugates is presented. Synthesis of a DNA dimer covalently linked to kanamycin and neomycin isothiocyanates has been carried out. The development of such conjugates will help couple the sequence specificity of nucleic acids to the electrostatic/shape complementarity of aminoglycoside antibiotics in binding nucleic acid targets.
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