
Bioorganic and Medicinal Chemistry Letters p. 277 - 280 (2003)
Update date:2022-07-30
Topics:
Stelmach, John E.
Liu, Luping
Patel, Sangita B.
Pivnichny, James V.
Scapin, Giovanna
Singh, Suresh
Hop, Cornelis E. C. A.
Wang, Zhen
Strauss, John R.
Cameron, Patricia M.
Nichols, Elizabeth A.
O'Keefe, Stephen J.
O'Neill, Edward A.
Schmatz, Dennis M.
Schwartz, Cheryl D.
Thompson, Chris M.
Zaller, Dennis M.
Doherty, James B.
The development of potent, orally bioavailable (in rat) and selective dihydroquinazolinone inhibitors of p38α MAP kinase is described. These analogues are hybrids of a pyridinylimidazole p38α inhibitor reported by Merck Research Laboratories and VX-745. O
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