De novo design, synthesis, and evaluation of novel nonsteroidal phenanthrene ligands for the estrogen receptor

DOI: 10.1021/jm020536q

Source and publish data:

Journal of Medicinal Chemistry p. 1408 - 1418 (2003)

Update date:2022-08-04

Topics:

Authors:

Schmidt, Jonathan M.

Mercure, Julie

Tremblay, Gilles B.

Pagé, Martine

Kalbakji, Aida

Feher, Miklos

Dunn-Dufault, Robert

Peter, Markus G.

Redden, Peter R.

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Article abstract of DOI:10.1021/jm020536q

Although there are many estrogen receptor antagonists with improved tissue selectivity profiles compared with tamoxifen, optimal tissue selectivity has not yet been demonstrated. As such there is still a need for additional diversity and new chemical scaf

Full text of DOI:10.1021/jm020536q

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