3876 J ournal of Medicinal Chemistry, 2002, Vol. 45, No. 18
Wright et al.
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Ack n ow led gm en t. We thank Professor Evan R.
Kantrowitz (Boston College) for a supply of porcine
kidney F16BPase. We thank Professor M. Raafat El-
Maghrabi (SUNY Stony Brook) for the kind provision
of the human and rat F16BPase cDNAs. We also thank
Dr. J ames D. Moyer for collaboration with the EGFR
tyrosine kinase inhibition assay and Dr. Rodney C.
Schnur for the preparation of 2a .
(10) (a) Dang, Q.; Erion, M. D.; Reddy, M. R.; Scarlato, G. R.;
Kasibhatla, S. R.; Reddy, K. R. Preparation of benzimid-
azolylphosphonates as inhibitors of fructose-1,6-bisphosphatase.
WO 98/39343 A1, 1998; Chem. Abstr. 1998, 129, 245147. (b)
Dang, Q.; Erion, M. D.; Reddy, M. R.; Robinson, E. D.; Kasib-
hatla, S. R.; Reddy, K. R. Preparation of novel purines for use
as inhibitors of fructose-1,6-bisphosphatase. WO 98/39344 A1,
1998; Chem. Abstr. 1998, 129, 260281. (c) Dang, Q.; Erion, M.
D.; Reddy, M. R.; Scarlato, G. R.; Kasibhatla, S. R.; Reddy, K.
R. Preparation of indoles and aza-indoles as inhibitors of
fructose-1,6-bisphosphatase. WO 98/39342 A1, 1998; Chem.
Abstr. 1998, 129, 245033. (d) Dang, Q.; Kasibhatla, S. R.; Reddy,
K. R.; Erion, M. D.; Reddy, M. R.; Agarwal, A. Preparation of
heteroaromatic phosphonates as fructose 1,6-bisphosphatase
inhibitors. WO 00/14095 A1, 2000; Chem. Abstr. 2000, 132,
222529.
Su p p or tin g In for m a tion Ava ila ble: IC50 values for
compounds 2-6 vs recombinant human liver F16Bpase, puri-
fied native rabbit liver F16Bpase, recombinant rat liver
F16Bpase, and recombinant porcine kidney F16Bpase. This
material is available free of charge via the Internet at http://
pubs.acs.org.
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