Synthesis and microbiological activity of some N-(2-hydroxy-4-substitutedphenyl)benzamides, phenylacetamides and furamides as the possible metabolites of antimicrobial active benzoxazoles

Article abstract of DOI:10.1016/S0014-827X(02)01226-0

The synthesis of some N-(2-hydroxy-4-substitutedphenyl)benzamides, phenylacetamides and furamides as the possible metabolites of benzoxazoles ( II(1-15)) was performed in order to determine their in vitro antimicrobial activity against three Gram-positive bacteria, two Gram-negative bacteria and the fungus Candida albicans and their activities were compared with several control drugs. The compounds II(11), II(12), and II(13) were found active at a MIC value of 12.5 μg/ml against the Gram-negative microorganism Pseudomonas aeruginosa. Most of the compounds show antibacterial activity at MIC a value of 25 μg/ml against the Gram-positive bacteria Staphylococcus aureus. For the antifungal activity against C. albicans, compound II(10) was found more active than the other derivatives. The antimicrobial activity of some of these benzamides, phenylacetamides (II(1) and II(10)) which are the possible metabolites of benzoxazoles, was also compared to their corresponding cyclic analogues III-IV. Compound II(10) possesses two dilutions better antifungal activity than its cyclic analogue, benzoxazole IV, against C. albicans.