(±)-Dioxolane-T ((±)-1-[(2β,4β)-2-(hydroxymethyl)-4-dioxolanyl]thymine). A new 2',3'-dideoxynucleoside prototype with in vitro activity against HIV

DOI: 10.1016/S0040-4039(01)93868-7

Source and publish data:

Tetrahedron Letters p. 6263 - 6266 (1989)

Update date:2022-08-03

Topics:

Authors:

Norbeck Norbeck

Spanton Spanton

Broder Broder

Mitsuya Mitsuya

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Article abstract of DOI:10.1016/S0040-4039(01)93868-7

A novel analogue of 3'-deoxythymidine, in which the 3'-carbon is replaced by oxygen, was synthesized in 5 steps from benzyloxyacetaldehyde dimethyl acetal and (±)-methyl glycerate. In ATH8 cells, this analogue showed significant inhibition of the infectiv

Full text of DOI:10.1016/S0040-4039(01)93868-7

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